Endocrine Abstracts

The onset of diabetic complications is attributed to sustained hyperglycemia which triggers the generation of free radicals and oxidative-related damage in the retina, renal glomerulus and peripheral nerves. Recent studies report that intense glycaemic control by the subcutaneous administration of insulin cannot completely restore the balance between reactive oxygen species and antioxidants. Preliminary studies in our laboratory indicate that transdermally delivered Syzygi...

The magnitude and duration of postprandial blood glucose elevations due to hydrolysis of carbohydrates are major risk factors of diabetes and coronary heart diseases. Inhibition of the key carbohydrate hydrolyzing enzymes in the small intestine suppresses postprandial blood glucose peaks and reduces chronic vascular complications in diabetic subjects. Recent reports indicate that Syzygium spp-derived oleanolic acid (OA) inhibits glucose transport in the small intestin...